Selected Publications

Anti-Aging Catabody Cardizyme

  1. Planque, S.A, Nishiyama, Y., Hara, M., Sonoda S., Murphy, S.K., Watanabe, K., Mitsuda, Y., Brown, E.L., Massey, R.J., Primmer, S.R., O’Nuallain, B. and Paul, S. Physiological IgM class catalytic antibodies selective for transthyretin amyloid. J Biol Chem. 2014;289(19):13243-58. PMCID: PMC4036335.
  2. Phay, M., Blinder, V., Macy, S., Greene, M.J., Wooliver, D.C., Liu, W., Planas, A., Walsh, D.M., Connors, L.H., Primmer, S.R., Planque, S., Paul, S., O’Nuallain, B. TTR Aggregate Specific Antibodies Recognize Cryptic Epitopes on Patient-Derived Amyloid Fibrils. Rejuvenation Res. 17(2):97-104, 2014.

Anti-Alzheimer Alzyme

  1. Planque, S.A., Nishiyama, Y., Sonoda, S., Lin, Y., Taguchi, H., Hara, M., Kolodziej, S., Mitsuda, Y., Gonzalez, V., Sait, H.B., Fukuchi, K., Massey, R.J., Friedland, R.P., O’Nuallain, B., Sigurdsson, E.M., Paul, S. Specific amyloid β clearance by a catalytic antibody construct. J Biol Chem. 2015;290(16):10229-41. PMCID: PMC4400338.
  2. Kou, J., Yang, J., Lim, J.E., Pattanayak, A., Song, M., Planque, S., Paul, S. and Fukuchi, K.I. Catalytic immunoglobulin gene delivery in a mouse model of Alzheimer’s disease: Prophylactic and therapeutic applications. Mol Neurobiol. 51(1):43-56, 2015. PMCID: PMC4198531.
  3. Nishiyama, Y., Taguchi, H., Hara, M., Planque, S.A., Mitsuda, Y., Paul S. Metal-dependent amyloid β-degrading catalytic antibody construct. J Biotechnol. 180:17-22, 2014. PMCID:PMC4512298.
  4. Paul, S., Planque, S., and Nishiyama, Y. Immunological origin and functional properties of catalytic autoantibodies to amyloid beta peptide. J Clin Immunol. 30 Suppl 1:S43-S49, 2010. PMCID:PMC3147076.
  5. Paul, S., Planque, S., and Nishiyama, Y. Beneficial catalytic immunity to amyloid β peptide. Proceedings of the Fourth Conference of Strategies for Engineered Negligible Senescence (SENS4). September 3-7, 2009. Queens’ College, Cambridge, United Kingdom. Rejuvenation Res. 13(2-3):179-187, 2010. PMCID:PMC2946056.
  6. Taguchi, H., Planque, S., Sapparapu, G., Boivin, S., Hara, M., Nishiyama, Y., and Paul, S. Exceptional amyloid β peptide hydrolyzing activity of non-physiological immunoglobulin variable domain scaffolds. J Biol Chem. 283(52):36724-36733, 2008. PMCID:PMC2606003.

HIV E-Vaccine Abzentek

  1. Planque, S.A., Mitsuda, Y., Chitsazzadeh, V., Gorantla, S., Poluektova, L., Nishiyama, Y., Ochsenbauer, C., Morris, M. K., Sapparapu, G., Hanson, C. V., Massey, R.J., and Paul, S. (2014) Deficient synthesis of class-switched, HIV neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen. AIDS. 28(15):2201-11, 2014. PMCID:PMC4573643.
  2. Planque, S., Nishiyama, Y., Mitsuda, Y., Taniguchi, R., Watanabe, K., Morris, M.K., Hanson, C.V., Massey, R.J., and Paul, S. Broad HIV neutralization by constitutive antibodies and their amplification by covalent HIV vaccination. AIDS 2012 XIX International AIDS Conference, July 22-27, 2012, Washington D.C.
  3. Nishiyama, Y., Planque, S.A., Hanson, C.V., Massey, R.J., and Paul, S. CD4 binding determinant mimicry for HIV vaccine design. Front. Immun. 3:383, 2012. [DOI: 10.3389/fimmu.2012.00383]. (Invited article). PMCID:PMC3523313.
  4. Planque, S.A., Mitsuda, Y., Nishiyama, Y., Karle, S., Boivin, S., Salas, M., Morris, M.K., Hara, M., Liao, G., Massey, R.J., Hanson, C.V., and Paul, S. Antibodies to a superantigenic glycoprotein 120 epitope as the basis for developing a HIV vaccine. J Immunol. 189(11):5367-5381, 2012. PMCID:PMC3755593.
  5. Paul, S., Planque, S., Nishiyama, Y., Escobar, M., and Hanson, C. Back to the future: covalent epitope-based HIV vaccine development. Expert Rev Vaccines. 9(9):1027-1043, 2010. PMCID:PMC3043596.
  6. Planque, S., Salas, M., Mitsuda, Y., Sienczyk, M., Escobar, M.A., Mooney, J.P., Morris, M.K., Nishiyama, Y., Ghosh, D., Kumar, A., Gao, F., Hanson, C.V., and Paul, S. Neutralization of genetically diverse HIV-1 strains by IgA antibodies to the gp120-CD4-binding site from long-term survivors of HIV infection. AIDS. 24(6):875-884, 2010. PMCID:PMC2881561. Erratum in AIDS. 2011 Jun 19;25(10):1345-1346.
  7. Nishiyama, Y., Planque, S., Mitsuda, Y., Nitti, G., Taguchi, H., Jin, L., Symersky, J., Boivin, S., Sienczyk, M., Salas, M., Hanson, C.V., and Paul, S. Towards effective HIV vaccination: induction of binary epitope reactive antibodies with broad HIV neutralizing activity. J Biol Chem. 284(44):30627-30642, 2009. PMCID:PMC2781617.

Technology Platform

  1. Planque, S., Massey R. Antibody Engineering. Encyclopedia of Life Sciences. In: eLS. John Wiley & Sons Ltd, Chichester. 2015. [DOI: 10.1002/9780470015902.a0001278.pub2].
  2. Planque, S.A., Nishiyama, Y., Sonoda, S., Lin, Y., Taguchi, H., Hara, M., Kolodziej, S., Mitsuda, Y., Gonzalez, V., Sait, H.B., Fukuchi, K., Massey, R.J., Friedland, R.P., O’Nuallain, B., Sigurdsson, E.M., Paul, S. Specific amyloid β clearance by a catalytic antibody construct. J Biol Chem., 290(16):10229-41, 2015. PMCID: PMC4400338.
  3. Planque, S.A, Nishiyama, Y., Hara, M., Sonoda S., Murphy, S.K., Watanabe, K., Mitsuda, Y., Brown, E.L., Massey, R.J., Primmer, S.R., O’Nuallain, B. and Paul, S. Physiological IgM class catalytic antibodies selective for transthyretin amyloid. J Biol Chem. 2014;289(19):13243-58. PMCID: PMC4036335.
  4. Brown, E.L., Nishiyama, Y., Dunkle, J.W., Aggarwal, S., Planque, S., Watanabe, K., Csencsits-Smith, K., Bowden, M.G., Kaplan, S.L., and Paul, S. Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection. J Biol Chem. 287(13):9940-9951, 2012. PMCID:PMC3323049.
  5. Sapparapu, G., Planque, S., Mitsuda, Y., McLean, G., Nishiyama, Y., and Paul, S. Constant domain-regulated antibody catalysis. J Biol Chem. 287(43):36096-36104, 2012. PMCID:PMC3476277.
  6. Sapparapu, G., Planque, S.A., Nishiyama, Y., Foung, S.K., and Paul, S. Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain. J Biol Chem. 284(36):24622-24633, 2009. PMCID:PMC2782051.
  7. Mitsuda, Y., Planque, S., Hara, M., Kyle, R., Taguchi, H., Nishiyama, Y., and Paul, S. Naturally occurring catalytic antibodies: Evidence for preferred development of the catalytic function in IgA class antibodies. Mol Biotechnol. 36:113-122, 2007.
  8. Nishiyama, Y., Mitsuda, Y., Taguchi, H., Planque, S., Salas, M., Hanson, C.V., and Paul, S. Towards covalent vaccination: Improved polyclonal HIV neutralizing antibody response induced by an electrophilic gp120 V3 peptide analog. J Biol Chem. 282(43):31250-31256, 2006.
  9. Paul, S., Karle, S., Planque, S., Taguchi, H., Salas, M., Nishiyama, Y., Handy, B., Hunter, R., Edmundson, A., and Hanson, C. Naturally occurring proteolytic antibodies: Selective IgM-catalyzed hydrolysis of HIV gp120. J Biol Chem. 279(38):39611-39619, 2004.
  10. Planque, S., Bangale, Y., Song, X.-T., Karle, S., Taguchi, H., Poindexter, B., Bick, R., Edmundson, A., Nishiyama, Y., and Paul, S. Ontogeny of proteolytic immunity: IgM serine proteases. J Biol Chem. 279: 14024-14032, 2004.
  11. Planque, S., Taguchi, H., Burr, G., Bhatia, G., Karle, S., Zhou, Y.-X., Nishiyama, Y., and Paul, S. Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activity. J Biol Chem. 278:20436-20443, 2003.
  12. Paul, S., Volle, D.J., Beach, C.M., Johnson, D.R., Powell, M.J., and Massey, R.J. Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody. Science. 244:1158-1162, 1989

Complete publication list is available here